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KMID : 0624620200530100500
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BMB Reports
2020 Volume.53 No. 10 p.500 ~ p.511
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Emerging roles of 14-3-3γ in the brain disorder
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Cho Eun-Sil
Park Jae-Yong
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Abstract
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14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3γ is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the distinctive levels of temporally and locally regulated 14-3-3γ expression in various brain disorders suggest that it could play a substantial role in brain plasticity of the diseased states. In this review, we introduce the various brain disorders reported to be involved with 14-3-3γ, and summarize the changes of 14-3-3γ expression in each brain disease. We also discuss the potential of 14-3-3γ for treatment and the importance of research on specific 14-3-3 isotypes for an effective therapeutic approach.
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KEYWORD
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14-3-3 gamma, 14-3-3 protein, 14-3-3γ, Brain disorders, Glioma, Inflammatory disease, Neurodegenerative disease, Neurodevelopmental disease, YWHAG
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